Answer :We checked in again with David G. Bailey, PhD, a professor of clinical pharmacology at Western Ontario University, who found that fruit juices (including orange, apple and grapefruit) consumed within two hours of taking certain medications dramati-cally weakened the drugs effectiveness. Bailey and colleagues did not test tomato juice spe-cifically, but he says, Fruits and vegetables contain a lot of flavonoids. We have been able to show that one of the important active in-gredients in grapefruit juice is naringin, which is a flavonoid. Thus, it is possible, but not yet shown, that another member of this family would also impair the absorption of certain drugs. Naringin is not found in tomato juice, however. Based on our current understanding, I would suggest that the way to get the most reliable effect is to take medications with a glass of water on an empty stomach at least two hours before eating, if possible.
