A randomized clinical trial (The U.S. POINTER trial) found that lifestyle changes benefited cognitive health in older adults at risk for cognitive decline and dementia. The study included 2,111 men and women ages 60 to 79 years at five clinical sites in the U.S. Participants had a sedentary lifestyle, suboptimal diet, and at least two other risk factors for cognitive decline and dementia (such as family history of memory impairment and cardiometabolic risk factors). They were randomly assigned to either a structured or self-guided lifestyle intervention program.
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