Answer :Bess Dawson-Hughes, MD, director of Tufts HNRCA Bone Metabolism Laboratory, responds: Youre right that more calcium is absorbed when calcium is taken in smaller amounts more frequently than when taken in larger amounts less frequently. When the amount exceeds 500 to 600 milligrams, absorption drops off even more dramatically. A practical approach for those who need more that 600 milligrams of supplementary calcium per day to reach their requirement is to split the dose.