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Articles December 2018 Issue

Leptin Discovery

Leptin is a hormone that has potential anti-obesity and anti-diabetes effects. Tufts’ researchers may have just discovered how it works.

More than 20 years after the discovery of the so-called “obesity hormone” leptin, a team at Tufts may have at last found this important compound’s target in the brain. In the 1960s, researchers made a surprising discovery: There was a biological mechanism behind the ravenous appetites of obese mice. Labs around the world immediately set out to find out what was making these mice so hungry.

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